Science & Evidence

Science designed to be challenged.

CoreX is built for scientific scrutiny: defined use cases, documented protocols, quality-controlled biology, auditable data systems, and transparent limitations. Biological intelligence is only valuable if it can be inspected, questioned, reproduced, and improved.

Validation

Blinded studies. Defined use cases. Inspectable evidence.

CoreX deploys the Quris-AI Bio-AI platform for sovereign, population-specific medicine programs. In defined drug-induced liver injury (DILI) benchmarks and blinded prospective studies, the platform has demonstrated performance against conventional biology-only and AI-only approaches. Full study designs, compound sets, comparator methods, confidence intervals, and limitations are available to qualified partners under NDA.

Platform evidence shown in defined DILI and blinded prospective study contexts. Not a general claim across all diseases, medicines, organs, or populations.

87%
Specificity

Liver-toxicity (DILI) prediction in a retrospective benchmark, versus 80% for 2D biology and 76% for 3D biology alone.

Quris-AI platform evidence
75%
Sensitivity

On the same DILI benchmark, versus 25% for 2D biology and 50% for 3D biology alone.

Quris-AI platform evidence
81%
Prospective accuracy

In independent blinded prospective studies, versus 68% for AI alone and 63% for biology alone.

Quris-AI platform evidence

In one program, the same platform flagged a safety signal in a major drug candidate that standard preclinical models did not catch.

"This technology flags drug toxicity that all our models completely missed."CAMS 2024 · blinded validation study

Evaluated in independent, blinded prospective studies with leading global pharmaceutical partners.

Metrics reflect defined contexts of use, such as liver-toxicity (DILI) prediction. Full study designs, compound sets, comparator methods, confidence intervals, and limitations are available to qualified partners under NDA.

Evidence Console

Every result, under glass.

Each result is shown with its context of use, study type, comparator, and its limitation. Evidence is only useful if you can see its edges.

Context of useDrug-induced liver injury (DILI) prediction
Study typeRetrospective benchmark
Comparator2D biology 80% · 3D biology 76%
87%Specificity
Not a general safety claim across all organs or mechanisms.
Quris-AI platform evidence
Context of useDrug-induced liver injury (DILI) prediction
Study typeRetrospective benchmark
Comparator2D biology 25% · 3D biology 50%
75%Sensitivity
Specific to this DILI benchmark and compound set.
Quris-AI platform evidence
Context of useProspective drug-safety prediction
Study typeIndependent blinded prospective study
ComparatorAI only 68% · biology only 63%
81%Prospective accuracy
Defined study contexts; not universal across all programs.
Quris-AI platform evidence
Contexts of Use

What each capability is for, and what it is not.

A model is never validated in general. It is validated for a defined context of use: a specific question, under specific conditions, with a stated boundary.

DILI / liver toxicity

  • StatusQualified partner programs
  • EvidenceDILI benchmarks and blinded study data
  • OutputToxicity-risk signal
  • Not claimedBroad safety prediction across all organs or mechanisms

PK / exposure-response

  • StatusDefined programs
  • EvidenceInternal and partner program data
  • OutputExposure and dose-response insight
  • Not claimedClinical dosing recommendation without additional evidence

Population cohort modeling

  • StatusGoverned programs
  • EvidenceIHLAD and CoreX deployment
  • OutputVariation across selected cohorts
  • Not claimedUniversal prediction for every individual

Multi-organ response

  • StatusResearch-stage
  • EvidenceInternal and exploratory work
  • OutputExploratory tissue-response data
  • Not claimedValidated whole-body clinical prediction
Proof Ladder

From biology to population intelligence.

  1. 01

    Biology

    Living donor-specific models.

  2. 02

    Assay

    Controlled organ-on-chip and organoid response systems.

  3. 03

    Dataset

    Structured biological response signals.

  4. 04

    Model

    Governed AI trained on biological response.

  5. 05

    Decision support

    Partner insight for defined use cases.

  6. 06

    Population intelligence

    Compounding evidence across cohorts.

Defined context of use

Every claim is tied to a specific scientific or development use case.

Protocol discipline

Clear endpoints, inclusion criteria, controls, and analysis plans.

Biological quality control

Documented characterization, acceptance criteria, and batch controls.

Model governance

Data provenance, version control, leakage prevention, and auditability.

CoreX capability status and public wording
CapabilityStatusPublic wording
Drug toxicity modelingQualified programsAvailable for qualified partner programs
Pharmacokinetic modelingDefined programsAvailable under defined programs
Population cohort modelingGoverned programsAvailable through governed population programs
Multi-organ responseResearch-stageResearch-stage / partner development
Regenerative applicationsFuture researchNot offered as a clinical therapy

Capability labels are intentionally high-level. Technical validation materials, study design, and context-specific performance data are available to qualified partners under appropriate confidentiality frameworks.

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