Living biology
Donor-specific Bio-Avatars, grown on a chip.
Sovereign Bio-Intelligence Engine
Precision medicine,
Precision medicine,
at population scale.
CoreX builds sovereign Bio-Intelligence Engines that turn living human biology into population-specific evidence for safer, more precise medicine.
Built from consented biology. Governed by design. Designed for defined scientific use.
Every cycle compounds: more signals, deeper understanding, and a stronger evidence base for research, development, policy, and precision-medicine strategy.
In partnership withInstitute for Healthier Living Abu Dhabi
Why It Matters
Same drug. Different biology.
Same drug. Different biology.
Different outcome.
Medicine is prescribed to individuals, but too often it is developed for averages. The same medicine can help one person, do nothing for the next, and cause toxicity in another. CoreX helps reveal those differences earlier, by studying medicines against living, donor-specific biological models and population cohorts before decisions reach patients.
Standard development
One model, generalized evidence, limited visibility into population variation.
CoreX
Living human models, population-specific response data, earlier insight into who may benefit and who may be at risk.
Same drug. Different biology. Different outcome. CoreX helps reveal those differences earlier.
How CoreX Works
Three layers, one engine.
CoreX combines living human biology, population health data, and governed AI. Each is covered below; together they form the Bio-Intelligence Engine.
Population health data
Governed, population-specific datasets.
Governed AI
Turns biology and data into decision-support intelligence.
Living Human Biology
Beating, outside the body.
Human heart tissue, grown from a single donor's cells, contracting in real time.
The Foundation
Meet the Bio-Avatar.
A Bio-Avatar is a living, donor-specific model of selected biological systems.
From a single donor's cells, CoreX grows living models of their biology, heart, liver, kidney, blood-brain barrier and more, and connects them on one chip through a shared microfluidic channel. Exposed to a medicine, the models generate donor-specific biological response data, within defined contexts of use. This is the living foundation the engine is built on, before any AI.
What each organ does
Heart
Beats. Contracts in real time, so we can read how a medicine affects the heart.
Liver
Metabolises. Breaks compounds down, revealing toxicity and clearance.
Kidney
Filters. Clears compounds from the system and flags renal stress.
Blood-brain barrier
Gatekeeps. Models whether a compound can cross from blood into the brain.
This is where CoreX begins: not with generic data, but with living human biology.
From one person to a population
The Data Layer
Grounded in population health data.
Living biology shows how a body responds. Population health data shows how those responses play out across real people. CoreX is built to ground its models in governed, population-specific data, designed for Emirati and regional cohorts, so evidence can reflect the populations it serves.
Population-specific datasets
Designed for Emirati and regional cohorts, so models can reflect the people they serve, not a global average.
Biobank integration pathway
A governed pathway to connect biobanks and health-system data, under agreed frameworks.
Real-world signals
Designed to capture how medicines behave across real populations, alongside the living-biology evidence.
Sovereign and secure
Data stays governed, localized, and auditable, owned by and valuable to the population.
The Intelligence Layer
Then, governed AI.
Living biology is the foundation, and population health data grounds it in real people. On top of both, governed AI learns how that biology responds, within defined contexts of use, and turns it into decision-support intelligence. Every prediction follows a governed path before it informs a decision.
Trained on living biology
Models learn from real organoid and iPSC response data, with documented training sets and a validation framework, not generic data.
Bench-to-brief governance
Outputs are reviewed, version-controlled, and interpreted within defined scientific and governance frameworks.
Bounded by design
Outputs carry uncertainty boundaries and clear criteria for where they do, and do not, apply.
Population-aware
Designed for regional populations, including Emirati and South Asian cohorts, so evidence can reflect the people it serves.
The Engine Room
One governed path, from consent to insight.
Scroll through the engine. Each layer builds on the one before it, and every cycle adds to the evidence.
Layer 01
It starts with consent.
Every CoreX program begins with consented, adult-derived cells from relevant populations, each traceable to its consent, purpose, and permitted use.
Layer 02
Then living human biology.
Those cells become Bio-Avatars and organ-on-chip systems: living, donor-specific models that show how human tissue actually responds.
Layer 03
Then population variation.
Bio-Avatars are organized into governed cohorts, so biological response can be studied across selected population groups, not a single average.
Layer 04
Then governed AI.
Auditable models learn from biological response within defined contexts of use, turning signal into decision-support intelligence.
The result
Evidence that compounds.
Each governed cycle adds to a sovereign biological intelligence asset that becomes more valuable as evidence accumulates.
Why Abu Dhabi
Where population-specific medicine
Where population-specific medicine
becomes infrastructure.
Abu Dhabi is building the infrastructure for the next era of health: genomics, precision medicine, AI, longevity science, and secure health-data systems. CoreX extends that ambition into living human biology, creating sovereign Bio-Intelligence Engines that help health systems understand medicine through the populations they serve.
In partnership with the Institute for Healthier Living Abu Dhabi, CoreX is helping build population-specific biological intelligence for the UAE.
What Makes CoreX Different
From one Bio-Avatar to population intelligence.
A single Bio-Avatar, a biological model grown from one donor's cells, can reveal important signals. But medicine is practiced across populations. CoreX builds governed cohorts of these donor-specific Bio-Avatars, so researchers can study biological variation across groups and generate insights relevant to real-world health systems. The goal is not to replace clinical judgment or clinical trials. The goal is to generate better human-relevant evidence earlier.
Validation
Blinded studies. Defined use cases. Inspectable evidence.
CoreX deploys the Quris-AI Bio-AI platform for sovereign, population-specific medicine programs. In defined drug-induced liver injury (DILI) benchmarks and blinded prospective studies, the platform has demonstrated performance against conventional biology-only and AI-only approaches.
Platform evidence shown in defined DILI and blinded prospective study contexts. Not a general claim across all diseases, medicines, organs, or populations.
87%
Specificity
Liver-toxicity (DILI) prediction in a retrospective benchmark, versus 80% for 2D biology and 76% for 3D biology alone.
Quris-AI platform evidence75%
Sensitivity
On the same DILI benchmark, versus 25% for 2D biology and 50% for 3D biology alone.
Quris-AI platform evidence81%
Prospective accuracy
In independent blinded prospective studies, versus 68% for AI alone and 63% for biology alone.
Quris-AI platform evidence
Applications
Built for serious partners.
CoreX supports partners working at the frontier of drug development, precision medicine, and population health, generating human-relevant evidence where biological diversity matters.
Pharma & Biotech
Better human evidence before human exposure
Earlier human-relevant evidence for toxicity, PK, dose-response, and candidate prioritization.
Governments & Health Systems
Biological intelligence for national precision medicine
Sovereign Bio-Intelligence Engines for population-specific medicine programs.
Strategic Partners
Infrastructure, data, and analytics
Biobanking, secure infrastructure, diagnostics, analytics, and translational research.
Ethics & Governance
No miracles. Better evidence.
CoreX works in one of the most sensitive areas of science, human biological intelligence, and that demands restraint. We build governed systems that help researchers and health systems make better decisions from better human evidence.
Clear boundaries. What CoreX does not do.
- Sell unapproved stem-cell therapies
- Claim to reverse aging clinically
- Use biological material without appropriate consent
- Treat AI outputs as medical advice
- Bypass clinical, regulatory, or ethics review
- Replace clinical trials or physician judgment
Leadership
Built by people who have done this before.
Sarah Miller
Co-founder & President, GCC Lead
Leads CoreX's GCC strategy, partnerships, and health-system deployment, turning frontier Bio-AI science into trusted infrastructure for governments and health systems.
Isaac Bentwich
Founder & Global CEO
Bio-AI pioneer and founder of the engine behind CoreX, with decades spent building computational biology and genomics ventures across multiple exits.
In the News
Announced as a UAE first.
Our partnership with the Institute for Healthier Living Abu Dhabi, to build the UAE's first bio-intelligence engine based on a specific population, was announced by the Abu Dhabi Media Office in December 2025 and covered across UAE and international media.
The Future of Medicine
The future of medicine will not be built from averages.
CoreX partners with institutions building the next layer of human-relevant, population-specific medicine.